Season 1
- Samantha Morton as Catherine de Medici
- Amrita Acharia as Aabis
- Enzo Cilenti ( ) as Cosimo Ruggeri
- Barry Atsma as Montmorency
- Nicholas Burns as Antoine de Bourbon
- Danny Kirrane as Louis de Bourbon
- Sennia Nanua as Rahima
- Beth Goddard as Antoinette de Guise
- Antonia Clarke as Mary Queen of Scots
- George Jaques as Francis II
- Charles Dance ( Game of Thrones ) as Pope Clement
- Liv Hill as Young Catherine
- Kiruna Stamell as Mathilde
- Colm Meaney ( Star Trek: DS9 ) as King Francis
- Rebecca Gethings as Queen Eleanor
- Ray Panthaki as Charles de Guise
- Raza Jaffrey as François de Guise
Serpent Queen (2022) [Season 1, Episode 1]
Medici Bitch (55 min)
Shown 11 Sep 22
Serpent Queen (2022) [Season 1, Episode 2]
To War Rather Than To Bed
Shown 18 Sep 22
Serpent Queen (2022) [Season 1, Episode 3]
The Price (57 min)
Shown 25 Sep 22
Serpent Queen (2022) [Season 1, Episode 4]
A New Era (55 min)
Shown 02 Oct 22
Serpent Queen (2022) [Season 1, Episode 5]
The First Regency
Shown 09 Oct 22
Serpent Queen (2022) [Season 1, Episode 6]
The Last Joust
Shown 16 Oct 22
Serpent Queen (2022) [Season 1, Episode 7]
An Attack on the King
Shown 23 Oct 22
Serpent Queen (2022) [Season 1, Episode 8]
A Queen Is Made
Shown 30 Oct 22
