Season 1
- Kasia Smutniak as Livia Drusilla
- Nadia Parkes as Young Livia
- Matthew McNulty ( ) as Gaius
- Ben Batt as Agrippa
- Christine Bottomley as Scribonia
- Claire Forlani as Octavia
- Colette Dalal Tchantcho as Antigone
- Peter Campion as Libo
- Liam Cunningham ( Game of Thrones ) as Livius
- Alex Lanipekun as Tycho
- Isabella Rossellini as Balbina
Domina (2021) [Season 1, Episode 1]
Fall
Shown 14th May 2021
Domina (2021) [Season 1, Episode 2]
Rise
Shown 14th May 2021
Domina (2021) [Season 1, Episode 3]
Family
Shown 14th May 2021
Domina (2021) [Season 1, Episode 4]
Secrets
Shown 14th May 2021
Domina (2021) [Season 1, Episode 5]
Plague
Shown 14th May 2021
Domina (2021) [Season 1, Episode 6]
Nightshade
Shown 14th May 2021
Domina (2021) [Season 1, Episode 7]
Treason
Shown 14th May 2021
Domina (2021) [Season 1, Episode 8]
Happiness
Shown 14th May 2021
Domina (2021) [Season 2, Episode 1
]